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DrX Whiz Niraj
100 Important Pharmacology One-Liners
Complete Notes for B.Pharm, D.Pharm, GPAT, and Medical Students
© DrX Whiz Niraj
01
General Pharmacology
1. Father of Pharmacology: Oswald Schmiedeberg.
2. Father of Indian Pharmacology: Col. Ram Nath Chopra.
3. Pharmacokinetics: What the body does to the drug (ADME).
4. Pharmacodynamics: What the drug does to the body.
5. Bioavailability: Fraction of drug reaching systemic circulation.
6. IV Route: Route with 100% bioavailability.
7. First Pass Metabolism: Mainly occurs in the Liver.
8. Pro-drug: Inactive form converted to active in the body (e.g. Enalapril).
9. Teratogenicity: Drug causing foetal abnormalities.
10. Idiosyncrasy: Genetically determined abnormal drug response.
02
Autonomic Nervous System
11. Cholinergic Transmitter: Acetylcholine.
12. Adrenergic Transmitter: Noradrenaline.
13. DOC for Anaphylactic Shock: Adrenaline.
14. Atropine Antidote: Physostigmine.
15. Glaucoma DOC: Pilocarpine (Miotic).
16. Myasthenia Gravis Test: Edrophonium (Tensilon test).
17. Organophosphate Antidote: Atropine + Pralidoxime.
18. Beta-1 Receptors: Present in Heart.
19. Beta-2 Receptors: Present in Bronchi/Lungs.
20. Propranolol: Non-selective Beta Blocker.
03
Cardiovascular System
21. Digoxin Mechanism: Na+/K+ ATPase Inhibition.
22. Digoxin Antidote: Digibind (Fab fragments).
23. ACE Inhibitor Suffix: -pril (Captopril).
24. ACE Inhibitor Side Effect: Dry Cough.
25. DOC for Angina: Sublingual Nitroglycerin.
26. Loop Diuretic: Furosemide (Lasix).
27. Potassium Sparing Diuretic: Spironolactone.
28. Statins: HMG-CoA Reductase Inhibitors.
29. DOC for Pregnancy HTN: Alpha-Methyldopa.
30. Amiodarone: Class III Anti-arrhythmic.
04
Antibiotics & Chemotherapy
31. Penicillin: Discovered by Alexander Fleming.
32. Cell Wall Inhibitors: Penicillins & Cephalosporins.
33. Tetracycline Side Effect: Teeth discoloration/Bone growth inhibition.
34. Chloramphenicol: Causes Grey Baby Syndrome.
35. Aminoglycosides: Ototoxicity & Nephrotoxicity.
36. Vancomycin: Causes Red Man Syndrome.
37. DOC for Syphilis: Benzathine Penicillin G.
38. DNA Gyrase Inhibitor: Fluoroquinolones (Ciprofloxacin).
39. Anti-TB Orange Urine: Rifampicin.
40. Multi-drug therapy: Used for Leprosy & TB.
41. DOC for Amoebiasis: Metronidazole.
42. Antifungal (Polyene): Amphotericin B.
43. HIV DOC: Zidovudine (AZT).
44. Sulfonamides: Inhibit Dihydropteroate Synthetase.
45. Co-trimoxazole: Trimethoprim + Sulfamethoxazole (1:5).
05
Central Nervous System
46. Levodopa: Precursor of Dopamine.
47. Carbidopa: Peripheral DOPA decarboxylase inhibitor.
48. Phenytoin Side Effect: Gingival Hyperplasia (Gum swelling).
49. DOC for Status Epilepticus: Diazepam/Lorazepam.
50. DOC for Absence Seizure: Ethosuximide.
51. Morphine Antidote: Naloxone.
52. Benzodiazepine Antidote: Flumazenil.
53. Lithium: DOC for Mania/Bipolar disorder.
54. Ketamine: Dissociative Anesthesia.
55. Chlorpromazine: Typical Antipsychotic.
06
Endocrine Drugs
56. Insulin: Secreted by Beta cells.
57. Metformin: Biguanide; does not cause hypoglycemia.
58. Sulfonylureas: Stimulate Insulin secretion.
59. DOC for Hypothyroidism: Levothyroxine (T4).
60. Oxytocin: Induction of Labour.
61. Cushing's Syndrome: Excess of Corticosteroids.
62. Mifepristone: Anti-progesterone; Medical abortion.
63. Tamoxifen: Selective Estrogen Receptor Modulator (SERM) for Breast Cancer.
64. Radioactive Iodine: Treatment of Hyperthyroidism.
65. Vasopressin (ADH): Treatment of Diabetes Insipidus.
07
Respiratory & GI System
66. Salbutamol: Beta-2 Agonist for Asthma.
67. Montelukast: Leukotriene Antagonist.
68. Omeprazole: Proton Pump Inhibitor (PPI).
69. Ranitidine: H2 Receptor Blocker.
70. Ondansetron: 5HT3 Antagonist; Anti-emetic.
71. Sucralfate: Ulcer protective agent.
72. Loperamide: Anti-diarrheal.
73. Metoclopramide: Prokinetic drug.
74. Theophylline: Methylxanthine for COPD.
75. Codeine: Opioid Antitussive (Cough suppressant).
08
NSAIDs & Analgesics
76. Aspirin: Irreversible COX inhibitor.
77. Aspirin Toxicity: Salicylism (Tinnitus).
78. Paracetamol Antidote: N-Acetylcysteine.
79. Selective COX-2 Inhibitor: Celecoxib.
80. Reye’s Syndrome: Aspirin in children with viral fever.
81. Diclofenac: Commonly used for joint pain.
82. Morphine: Causes Pin-point pupil (Miosis).
83. Indomethacin: DOC for closing Patent Ductus Arteriosus (PDA).
84. Allopurinol: Chronic Gout treatment.
85. Colchicine: Acute Gout treatment.
09
Hematology & Blood
86. Heparin Antidote: Protamine Sulfate.
87. Warfarin Antidote: Vitamin K.
88. Iron Antidote: Desferrioxamine.
89. Vitamin B12: Cyanocobalamin (Pernicious anemia).
90. Streptokinase: Thrombolytic (Clot buster).
91. Tranexamic Acid: Antifibrinolytic (Stops bleeding).
92. Erythropoietin: Increases RBC production.
93. Heparin Test: aPTT.
94. Warfarin Test: PT/INR.
95. Aspirin: Anti-platelet drug.
10
Miscellaneous
96. Disulfiram: Alcohol aversion therapy.
97. Sildenafil: PDE-5 Inhibitor for Erectile Dysfunction.
98. Methotrexate: Folic acid antagonist (Anticancer).
99. Cyclosporine: Immunosuppressant for Transplant.
100. D-Penicillamine: Chelating agent for Copper (Wilson’s disease).